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Wednesday, October 14, 2020 | History

2 edition of Platelet Responses and Metabolism found in the catalog.

Platelet Responses and Metabolism

Holmsen

Platelet Responses and Metabolism

Receptors and Metabolism

by Holmsen

  • 302 Want to read
  • 38 Currently reading

Published by CRC .
Written in English

    Subjects:
  • Haematology,
  • Medical / Hematology,
  • Hematology

  • The Physical Object
    FormatHardcover
    Number of Pages360
    ID Numbers
    Open LibraryOL11560032M
    ISBN 100849358981
    ISBN 109780849358982

    ALOX12 (EC ), also known as arachidonate lipoxygenase, lipoxygenase, 12S-Lipoxygenase, LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p ALOX12 is 75 kilodalton protein composed of amino s: ALOX12, LOX, 12S-LOX, LOG12, .   More information: Trevor P. Fidler et al. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function, Cell .

    Platelet functions other than those enumerated above (eg, the role of platelets in inflammatory and immune responses, as well as specific disorders characterized by local or systemic platelet activation) have been reviewed elsewhere. NORMAL VALUES. The normal range for platelet counts in the adult is discussed separately. REVIEW Role of platelet-derived growth factors in physiology and medicine Johanna Andrae,1,2 Radiosa Gallini,1 and Christer Betsholtz1,2,3,4 1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 77 Stockholm, Sweden; 2Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Institutet, SE 77 Stockholm, Sweden; 3Department.

      In keeping with the rising incidence of atherothrombotic disease, reliable platelet function testing has become more important. In acute coronary syndromes (ACS), platelets often play a starring role in the pathogenesis of disease and are a critical target for pharmacotherapy (1,2). Platelet release occurs when the MK cytoplasm is trans-formed into proplatelets, followed by the release of – new platelets/cell (Long, ). Compensatory responses of marrow MKs increase platelet production through an increase in cell proliferation, maturation and release of platelets, as.


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Platelet Responses and Metabolism by Holmsen Download PDF EPUB FB2

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate.

Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets. The problem of whether one or more receptors are involved in platelet activation by ADP was long debated.

15,18,19 However, some observations, based on different patterns of modulation of platelet responses to ADP by inhibitors such as p-chloromercuribenzene sulfonic acid (pCMBS), suggested the possibility that two receptors are involved: one. Study identifies multiple roles of glucose metabolism in platelet activation and survival Platelets, the cells in blood that enable clotting, are highly reliant on their ability to metabolize glucose, according to a new study by researchers at the University of Iowa.

Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate.

Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets Book Edition: 1. Lipid Metabolism and Signaling in Platelet Function and platelet responses have major pathogenic roles in atherothrombosis.

This review highlights recent findings on the impact of aberrant. Vox Sang. ;40 Suppl Energy Metabolism and platelet responses. Holmsen H. PMID: [PubMed - indexed for MEDLINE] Publication Types:Cited by: Platelets: From Formation to Function 7 activation is the production and release of soluble agonists at the site of damage [26 ], which act in an autocrine and paracrine manner to amplify platelet.

Also that if and when this problem of con­ trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses.

Abstract. In the last few years our work has concentrated on lipid changes associated with platelet responses. We found initially that phosphatidic acid is rapidly formed in thrombin-stimulated platelets due to the breakdown of inositol phospholipids [1].Cited by: 1.

Measurement. Platelet concentration is measured either manually using a hemocytometer, or by placing blood in an automated platelet analyzer using electrical impedance, such as a Coulter counter. The normal range (99% of population analyzed) for platelets in healthy Caucasians istoper cubic millimeter (a mm 3 equals a microliter).

or – × 10 9 per : D Thromboxane A2 (TxA2) is in the family of lipids known as eicosanoids, which are metabolites of arachidonic acid generated by the sequential action of three enzymes – phospholipase A2, COX-1/COX-2 and TxA2 Synthase (TXAS).

TxA2 was originally described as being released from platelets and is now known to be released by a variety of other cells including macrophages, neutrophils, and Author: Dane Rucker, Amit S.

Dhamoon. Get this from a library. Mechanisms of stimulus-response coupling in platelets. [J Westwick;] -- Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and.

Platelets - winner of a Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.

Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases Book Edition: 3. Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers Platelets is a comprehensive new textbook of 61 chapters and 1, pages (approx.) written by over world leaders in the ets is a single definitive source of state-of-the-art knowledge about platelets.

There has been no textbook that specifically and fully Reviews: 1. Looking for ways to naturally increase your platelet count. Vitamin B, vitamin C, and iron are just some of the supplements you should be including in your diet to increase your platelet count.

Platelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis.

Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet indices like mean platelets volume (MPV), platelets distributed width (PDW), and platelet crit (PCT) are useful as Cited by: Platelets from patients with iron‐deficiency anaemia showed abnormal aggregation responses to dopamine and 5‐HT.

This abnormality, which was corrected after treatment of the anaemia, appears to be related to a change in the platelet itself since the aggregation response of platelets from iron‐deficient subjects suspended in normal plasma Cited by: Thrombin is the most powerful platelet activator, initiating an entire complement of platelet responses (shape change, granule secretion, TxA 2 synthesis, aggregation etc.).

Thrombin can activate platelets at extremely low concentrations and within seconds, increases cytosolic level of Ca 2+, eliciting downstream signalling : Laura Twomey, Robert G. Wallace, Philip M. Cummins, BernardDegryse, Sinead Sheridan, Michael Harriso. We will focus on (1) platelet activation including mean platelet volume, membrane fluidity and coated platelets, (2) serotonin metabolism, (3) APP isoforms and processing enzymes, including secretases, (4) oxidative stress and radicals, including nitric oxide metabolism and mitochondrial pathologies, including cytochrome-c oxidase and monoamino Cited by: 2.

Multiple roles of glucose metabolism identified in platelet activation and survival: Research may inform how increased glucose metabolism .Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of : Hardcover.

This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of Brand: Springer Berlin Heidelberg.